Trajectories of body mass index from early adulthood to late midlife and incidence of total knee arthroplasty for osteoarthritis: findings from a prospective cohort study

SM Hussain; IN Ackerman; Y Wang; DR English; AE Wluka; GG Giles; FM Cicuttini

Journal article

Trajectories of body mass index from early adulthood to late midlife and incidence of total knee arthroplasty for osteoarthritis: findings from a prospective cohort study

SM Hussain, IN Ackerman, Y Wang, DR English, AE Wluka, GG Giles, FM Cicuttini

Osteoarthritis and Cartilage | ELSEVIER SCI LTD | Published : 2023

DOI: 10.1016/j.joca.2022.11.013

Abstract

Objective: To examine the association between body mass index (BMI) trajectories from early adulthood to late midlife and risk of total knee arthroplasty (TKA) for osteoarthritis. Methods: 24,368 participants from the Melbourne Collaborative Cohort Study with weight collected during 1990–1994, 1995–1998, and 2003–2007, recalled weight at age 18–21 years, and height measured during 1990–1994 were included. Incident TKA from 2003 to 2007 to December 2018 was determined by linking cohort records to the National Joint Replacement Registry. Results: Using group-based trajectory modelling, six distinct trajectories (TR) of BMI from early adulthood (age 18–21 years) to late midlife (approximately 6..

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University of Melbourne Researchers

Dallas English Author

Graham Giles Author

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Awarded by VicHealth

Funding Acknowledgements

The recruitment of the Melbourne Collaborative Cohort Study was funded by VicHealth and Cancer Council Victoria. This study was funded by grants from the National Health and Medical Research Council (NHMRC; 209057, 251533, 396414, 623208) , and was further supported by infrastructure provided by Cancer Council Victoria. SMH is the recipient of NHMRC Early Career Fellowship (APP1142198) , YW is the recipient of NHMRC Translating Research Into Practice Fellowship (APP1168185) , and FMC is the recipient of NHMRC Investigator Grant (APP1194829) .